Diethyl Ether → 4-Methyl-2,3,5-trifluoro-6-(4-trifluoromethylphenyl)pyridine

HRID 1556421Notes

Reaction equation

HRID 1556421 reaction equation
[Br:6][c:7]1[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:17][c:18]1[c:19]([F:27])[c:20]([F:26])[n:21][c:22]([F:25])[c:23]1[F:24].[CH3:28][CH2:29][O:30][CH2:31][CH3:32]>>[c:7]1(-[c:22]2[n:21][c:20]([F:26])[c:19]([F:27])[c:18]([CH3:17])[c:23]2[F:24])[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 46613162,3,5,6-Tetrafluoro-4-methylpyridineHCID 178418339Butyllithium

Product 1

HCID 114377574-Methyl-2,3,5-trifluoro-6-(4-trifluoromethylphenyl)pyridine

Sources & evidence

ORD record
ord-aa27e48c06964763bbfa66af0ba5a631
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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