Dimethylformamide → (2-Cyclobutylthiazol-4-yl)(9-(3-fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone

HRID 1556645노트

반응식

[CH3:59][CH2:60][N:61]([CH2:62][CH3:63])[CH2:64][CH3:65].[CH:47]1([c:51]2[s:52][cH:53][c:54]([C:56](=[O:57])[OH:58])[n:55]2)[CH2:48][CH2:49][CH2:50]1.[O:25]1[CH2:26][CH2:27][NH:28][CH2:29][C:30]12[CH2:31][CH2:32][N:33]([CH2:36][c:37]1[cH:38][c:39]([CH2:44][CH2:45][OH:46])[cH:40][c:41]([F:43])[cH:42]1)[CH2:34][CH2:35]2.[O:66]=[CH:67][N:68]([CH3:69])[CH3:70].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[O:25]1[CH2:26][CH2:27][N:28]([C:56]([c:54]2[cH:53][s:52][c:51]([CH:47]3[CH2:48][CH2:49][CH2:50]3)[n:55]2)=[O:57])[CH2:29][C:30]12[CH2:31][CH2:32][N:33]([CH2:36][c:37]1[cH:38][c:39]([CH2:44][CH2:45][OH:46])[cH:40][c:41]([F:43])[cH:42]1)[CH2:34][CH2:35]2