3-Bromopropionitrile → 3-(2'-oxo-6H-spiro[benzofuro[6,5-d][1,3]dioxole-7,3'-indoline]-1'-yl)propanenitrile

HRID 1556686Notes

Reaction equation

HRID 1556686 reaction equation
[Br:1][CH2:2][CH2:3][C:4]#[N:5].[Br:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([C:13]#[N:14])[cH:15]1.[NH:16]1[C:17](=[O:36])[C:18]2([CH2:19][O:20][c:21]3[c:22]2[cH:23][c:24]2[c:25]([cH:29]3)[O:26][CH2:27][O:28]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][c:35]21.[NH:37]1[c:38]2[c:39]([cH:40][cH:41][cH:42][cH:43]2)[C:44]2([CH2:45][O:46][c:47]3[cH:48][c:49]4[c:50]([cH:51][c:52]32)[CH2:53][CH2:54][O:55]4)[C:56]1=[O:57]>>[CH2:2]([CH2:3][C:4]#[N:5])[N:16]1[C:17](=[O:36])[C:18]2([CH2:19][O:20][c:21]3[c:22]2[cH:23][c:24]2[c:25]([cH:29]3)[O:26][CH2:27][O:28]2)[c:30]2[cH:31][cH:32][cH:33][cH:34][c:35]21

Participants

5

Reactant 4

HCID 170203-BromopropionitrileHCID 97249Benzonitrile, 3-(bromomethyl)-HCID 53375495spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-oneHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one

Product 1

HCID 593525813-(2'-oxo-6H-spiro[benzofuro[6,5-d][1,3]dioxole-7,3'-indoline]-1'-yl)propanenitrile

Sources & evidence

ORD record
ord-60447c4d0e0d4f92a47cd9dbaa528e29
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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