(5-Isopropylthiophen-3-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone → 5-[1-[tert-butyl(dimethyl)silyl]oxy-2-[[2-methyl-1-[3-[[4-(5-propan-2-ylthiophene-3-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propan-2-yl]amino]ethyl]-8-hydroxy-1H-quinolin-2-one

HRID 1556907Notes

Reaction equation

HRID 1556907 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH:7]([CH2:8][NH:9][C:10]([CH2:11][c:12]1[cH:13][c:14]([CH:15]=[O:16])[cH:17][cH:18][cH:19]1)([CH3:20])[CH3:21])[c:22]1[c:23]2[cH:24][cH:25][c:26](=[O:33])[nH:27][c:28]2[c:29]([OH:32])[cH:30][cH:31]1)([CH3:34])[CH3:35].[CH:36]([CH3:37])([CH3:38])[c:39]1[cH:40][c:41]([C:44](=[O:45])[N:46]2[CH2:47][CH2:48][O:49][C:50]3([CH2:51]2)[CH2:52][CH2:53][NH:54][CH2:55][CH2:56]3)[cH:42][s:43]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH:7]([CH2:8][NH:9][C:10]([CH2:11][c:12]1[cH:13][c:14]([CH2:15][N:54]2[CH2:53][CH2:52][C:50]3([O:49][CH2:48][CH2:47][N:46]([C:44]([c:41]4[cH:40][c:39]([CH:36]([CH3:37])[CH3:38])[s:43][cH:42]4)=[O:45])[CH2:51]3)[CH2:56][CH2:55]2)[cH:17][cH:18][cH:19]1)([CH3:20])[CH3:21])[c:22]1[c:23]2[cH:24][cH:25][c:26](=[O:33])[nH:27][c:28]2[c:29]([OH:32])[cH:30][cH:31]1)([CH3:34])[CH3:35]

Participants

3

Reactant 2

HCID 57989215(5-Isopropylthiophen-3-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanoneHCID 873421903-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]-2-methylpropyl]benzaldehyde

Product 1

HCID 672922385-[1-[tert-butyl(dimethyl)silyl]oxy-2-[[2-methyl-1-[3-[[4-(5-propan-2-ylthiophene-3-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propan-2-yl]amino]ethyl]-8-hydroxy-1H-quinolin-2-one

Sources & evidence

ORD record
ord-72f214f3340443318ccc2257ac5493e4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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