1-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazine → 1-[4-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazin-1-yl]-2-(4-chloro-5-methyl-3-pyrimidin-2-ylpyrazol-1-yl)ethanone

HRID 1556970Notes

Reaction equation

HRID 1556970 reaction equation
[Cl:17][c:18]1[c:19](-[c:28]2[n:29][cH:30][cH:31][cH:32][n:33]2)[n:20][n:21]([CH2:24][C:25](=[O:26])[OH:27])[c:22]1[CH3:23].[Cl:1][c:2]1[cH:3][c:4]([F:16])[c:5]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[cH:6][c:7]1[O:8][CH3:9]>>[Cl:1][c:2]1[cH:3][c:4]([F:16])[c:5]([N:10]2[CH2:11][CH2:12][N:13]([C:25]([CH2:24][n:21]3[n:20][c:19](-[c:28]4[n:29][cH:30][cH:31][cH:32][n:33]4)[c:18]([Cl:17])[c:22]3[CH3:23])=[O:26])[CH2:14][CH2:15]2)[cH:6][c:7]1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 576427921-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazineHCID 598139802-(4-Chloro-5-methyl-3-pyrimidin-2-ylpyrazol-1-yl)acetic acid

Product 1

HCID 578402121-[4-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazin-1-yl]-2-(4-chloro-5-methyl-3-pyrimidin-2-ylpyrazol-1-yl)ethanone

Sources & evidence

ORD record
ord-dbfe2cfe8bce40adae0d7baf2b0ecdac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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