HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15576Generated: October 26, 2026
Butanal → (5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester
https://huagongshe.com/reaction/15576
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Butanal | HCID 261 | — |
| Reactant | Glycine,n-[2-amino-4-[[(1,1-dimethylethoxy)carbonyl]amino]phenyl]-,1,1-dimethylethyl ester | HCID 67199974 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester | HCID 67199280 | — |
Reaction Steps
Butyraldehyde (0.65 mL, 9.0 mmol) and acetic acid (7 drops) were added to a solution of (2-amino-4-tert-butoxycarbonylamino-phenylamino)-acetic acid tert-butyl ester (2.2 g, 6.5 mmol) in EtOH (100 mL), and stirred overnight at 70° C. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure to give the crude sub-title compound that was used without further purification. MS calculated for C21H31N3O4+H: 390, observed: 390.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07732618B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-bc04f7d1b41c416f8af2a5442656c18d |
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| Source note | uspto-grants-2010_06 |
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