N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → N-({1-[4-Hydroxy-4-(2-methylsulfanyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

HRID 155761Notes

Reaction equation

HRID 155761 reaction equation
[CH3:1][S:2][c:3]1[s:4][c:5]([C:8]2([OH:18])[CH2:9][CH2:10][C:11]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:16][CH2:17]2)[cH:6][n:7]1.[NH:19]1[CH2:20][CH:21]([NH:23][C:24](=[O:25])[CH2:26][NH:27][C:28]([c:29]2[cH:30][c:31]([C:35]([F:36])([F:37])[F:38])[cH:32][cH:33][cH:34]2)=[O:39])[CH2:22]1>>[CH3:1][S:2][c:3]1[s:4][c:5]([C:8]2([OH:18])[CH2:9][CH2:10][CH:11]([N:19]3[CH2:20][CH:21]([NH:23][C:24](=[O:25])[CH2:26][NH:27][C:28]([c:29]4[cH:30][c:31]([C:35]([F:36])([F:37])[F:38])[cH:32][cH:33][cH:34]4)=[O:39])[CH2:22]3)[CH2:16][CH2:17]2)[cH:6][n:7]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 593616378-(2-Methylsulfanyl-thiazol-5-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

Product 1

HCID 46240687N-({1-[4-Hydroxy-4-(2-methylsulfanyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-ef0940c2ab1144a2b064d0d49077e11e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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