2,5-Difluoro-4-methoxyphenylboronic acid → 4-amino-8-(2,5-difluoro-4-methoxy-phenyl)-N-propyl-cinnoline-3-carboxamide

HRID 1558015Notes

Reaction equation

HRID 1558015 reaction equation
[F:19][c:20]1[c:21]([B:29]([OH:30])[OH:31])[cH:22][c:23]([F:28])[c:24]([O:26][CH3:27])[cH:25]1.[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7]([Br:12])[cH:8][cH:9][cH:10][c:11]12>>[NH2:1][c:2]1[c:3]([C:13](=[O:14])[NH:15][CH2:16][CH2:17][CH3:18])[n:4][n:5][c:6]2[c:7](-[c:21]3[c:20]([F:19])[cH:25][c:24]([O:26][CH3:27])[c:23]([F:28])[cH:22]3)[cH:8][cH:9][cH:10][c:11]12

Participants

3

Reactant 2

HCID 36965512,5-Difluoro-4-methoxyphenylboronic acidHCID 140123264-Amino-8-bromo-N-propylcinnoline-3-carboxamide

Product 1

HCID 236299654-amino-8-(2,5-difluoro-4-methoxy-phenyl)-N-propyl-cinnoline-3-carboxamide

Sources & evidence

ORD record
ord-77fc69b77fa04638b3a731a17b86b95c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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