1-Chloroethyl chloroformate → Morpholine, 2-[[2-(difluoromethoxy)phenyl]methyl]-

HRID 1558309Notes

Reaction equation

HRID 1558309 reaction equation
[C:25]([N:26]1[CH2:27][CH2:28][O:29][CH:30]([CH2:31][c:32]2[cH:33][cH:34][cH:35][c:36]([CH:37]=[CH:38][c:39]3[cH:40][n:41][cH:42][cH:43][cH:44]3)[cH:45]2)[CH2:46]1)([O:47][C:48]([CH3:49])([CH3:50])[CH3:51])=[O:52].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH2:14][c:15]2[c:16]([O:21][CH:22]([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[O:11][CH2:12][CH2:13]1.[Cl:53][C:54]([O:55][CH:56]([Cl:57])[CH3:58])=[O:59]>>[NH:8]1[CH2:9][CH:10]([CH2:14][c:15]2[c:16]([O:21][CH:22]([F:23])[F:24])[cH:17][cH:18][cH:19][cH:20]2)[O:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 5213051-Chloroethyl chloroformateHCID 67073057N-benzyl-2-(2-difluoromethoxy-benzyl)-morpholineHCID 77221556HCID 77221556, compound

Product 1

HCID 11601200Morpholine, 2-[[2-(difluoromethoxy)phenyl]methyl]-

Sources & evidence

ORD record
ord-7df7234c80f741a3853eaeba8e95908f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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