Pyrazine, 2-(chloromethyl)- → 1'-(pyrazin-2-ylmethyl)spiro[3,7-dihydro-2H-furo[2,3-g][1,4]benzodioxine-8,3'-indole]-2'-one

HRID 1559894Notes

Reaction equation

HRID 1559894 reaction equation
[Cl:1][CH2:2][c:3]1[n:4][cH:5][cH:6][n:7][cH:8]1.[Cl:9][CH2:10][c:11]1[c:12]([C:13]([F:14])([F:15])[F:16])[n:17][cH:18][cH:19][cH:20]1.[NH:21]1[C:22](=[O:42])[C:23]2([CH2:24][O:25][c:26]3[cH:27][c:28]4[c:29]([cH:34][c:35]32)[O:30][CH2:31][CH2:32][O:33]4)[c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]21.[NH:43]1[c:44]2[c:45]([cH:46][cH:47][cH:48][cH:49]2)[C:50]2([c:51]3[c:52]([cH:53][c:54]4[c:59]([cH:60]3)[O:58][CH2:57][CH2:56][O:55]4)[O:61][CH2:62]2)[C:63]1=[O:64]>>[CH2:2]([c:3]1[n:4][cH:5][cH:6][n:7][cH:8]1)[N:21]1[C:22](=[O:42])[C:23]2([CH2:24][O:25][c:26]3[cH:27][c:28]4[c:29]([cH:34][c:35]32)[O:30][CH2:31][CH2:32][O:33]4)[c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]21

Participants

4

Reactant 3

HCID 170169Pyrazine, 2-(chloromethyl)-HCID 534172573-(Chloromethyl)-2-(trifluoromethyl)pyridineHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydro2×

Product 1

HCID 722686351'-(pyrazin-2-ylmethyl)spiro[3,7-dihydro-2H-furo[2,3-g][1,4]benzodioxine-8,3'-indole]-2'-one

Sources & evidence

ORD record
ord-1d5d1624cd314f22acd71f64180c89c0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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