1,1-Dimethylethyl 3-(4-aminophenyl)-1-pyrrolidinecarboxylate → 3-{4-[7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 156052Notes

Reaction equation

HRID 156052 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([c:13]2[cH:14][cH:15][c:16]([NH2:19])[cH:17][cH:18]2)[CH2:11][CH2:12]1.[CH3:20][O:21][c:22]1[c:23](-[c:28]2[cH:29][cH:30][c:31]3[cH:32][n:33][c:34]([O:37][S:38]([C:39]([F:40])([F:41])[F:42])(=[O:43])=[O:44])[n:35][n:36]23)[cH:24][cH:25][cH:26][cH:27]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([c:13]2[cH:14][cH:15][c:16]([NH:19][c:34]3[n:33][cH:32][c:31]4[cH:30][cH:29][c:28](-[c:23]5[c:22]([O:21][CH3:20])[cH:27][cH:26][cH:25][cH:24]5)[n:36]4[n:35]3)[cH:17][cH:18]2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 573650691,1-Dimethylethyl 3-(4-aminophenyl)-1-pyrrolidinecarboxylateHCID 86661678Trifluoro-methanesulfonic acid 7-(2-methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester

Product 1

HCID 667121063-{4-[7-(2-Methoxy-phenyl)-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino]-phenyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-16a18aa244e64faa82126cb39928f95a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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