反应详情

Oseltamivir phosphate (20 gm, HPLC purity: 97%) is stirred with water (100 ml) and methylene chloride (100 ml) for 10 minutes at 25-30° C. and then pH of the mass is adjusted to 9-10 with liquor ammonia. Separated the layers, the organic layer is subjected to carbon treatment and filtered on hiflo bed. Washed the hiflo bed with methylene chloride (20 ml) and then distilled the organic layer under vacuum at 40° C. to give 16.5 gm of oseltamivir free base as a residue.

1. customSeparated the layers
2. filtrationfiltered on hiflo bed
3. washWashed the hiflo bed with methylene chloride (20 ml)
4. distillationdistilled the organic layer under vacuum at 40° C.