HRID15609

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11553

Propanoic acid, 3-bromo-

C3H5BrO2

结构：CCOC(=O)Nc1ccc2ncc3c(NC(=O)OCC)cc(-c4ccccc4)cc3c2c1

HCID21966918

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Nc1ccc2ncc3c(NC(=O)OCC)cc(-c4ccccc4)c(CCC(=O)O)c3c2c1

HCID68693544

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7416

Nitrobenzene

C6H5NO2

PROCEDURE

实验过程

2,7-Biscarboethoxyamino-9-phenylphenanthridine (22-1, 1 equiv.), prepared by the method of Watkins (1952) J. Chem. Soc. 3059, is combined with 3-bromopropionic acid (2.5 equiv.; Aldrich Chemical Co., Milwaukee, Wis.) and is heated in nitrobenzene at 100° C. for 4-6 hours. Following cooling to room temperature the crude product is precipitated by addition of ether. The product 22-2 is isolated by filtration and used directly.

WORKUP

后处理

customis precipitated by addition of ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b6399fa9765c47cd9c2f163023dd8697
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07732628B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([NH:6][C:7]1[CH:20]=[CH:19][C:18]2[C:9](=[C:10]3[C:15](=[CH:16][N:17]=2)[C:14]([NH:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:13][C:12]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:11]3)[CH:8]=1)([O:3][CH2:4][CH3:5])=[O:2].Br[CH2:34][CH2:35][C:36]([OH:38])=[O:37]>[N+](C1C=CC=CC=1)([O-])=O>[C:36]([CH2:35][CH2:34][C:11]1[C:10]2[C:15](=[CH:16][N:17]=[C:18]3[C:9]=2[CH:8]=[C:7]([NH:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH:20]=[CH:19]3)[C:14]([NH:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:13][C:12]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)([OH:38])=[O:37]