Pyridine → Ethyl 4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidine-1-carboxylate
Reaction equation
[CH2:31]([Cl:32])[Cl:33].[Cl:1][c:2]1[c:3]([C:15]([F:16])([F:17])[F:18])[cH:4][c:5]([C:8]2([OH:14])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:6][cH:7]1.[Cl:25][C:26](=[O:27])[O:28][CH2:29][CH3:30].[cH:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>>[Cl:1][c:2]1[c:3]([C:15]([F:16])([F:17])[F:18])[cH:4][c:5]([C:8]2([OH:14])[CH2:9][CH2:10][N:11]([C:26](=[O:27])[O:28][CH2:29][CH3:30])[CH2:12][CH2:13]2)[cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-32284e6ab51641c08c14b62aaa2a9663
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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