Methyl 4-(bromomethyl)benzoate → 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-1,1-dimethyl-ethoxymethyl}-benzoic acid methyl ester

HRID 1562489Notes

Reaction equation

HRID 1562489 reaction equation
[Br:30][CH2:31][c:32]1[cH:33][cH:34][c:35]([C:36](=[O:37])[O:38][CH3:39])[cH:40][cH:41]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([C:14]([CH3:15])([OH:16])[CH3:17])[CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[cH:24][c:25]([F:29])[c:26]([F:28])[cH:27]3)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([C:14]([CH3:15])([O:16][CH2:31][c:32]2[cH:33][cH:34][c:35]([C:36](=[O:37])[O:38][CH3:39])[cH:40][cH:41]2)[CH3:17])[CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)[cH:24][c:25]([F:29])[c:26]([F:28])[cH:27]3)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 666192681-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-1-cyclohexyl-2-methyl-propan-2-ol

Product 1

HCID 666193234-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-1,1-dimethyl-ethoxymethyl}-benzoic acid methyl ester

Sources & evidence

ORD record
ord-e23a5617556f4f4db48ebb732b7fa165
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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