6-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one → Benzyl 4-{4-[2-(2,5-difluorobenzyloxy)ethoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

HRID 1563232Notes

Reaction equation

HRID 1563232 reaction equation
[Cl:37][CH2:38][c:39]1[cH:40][cH:41][c:42]2[c:43]([cH:54]1)[N:44]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[C:45](=[O:48])[CH2:46][O:47]2.[F:1][c:2]1[c:3]([CH2:4][O:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([OH:31])[CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][c:25]4[cH:26][cH:27][cH:28][cH:29][cH:30]4)[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:32][c:33]([F:36])[cH:34][cH:35]1>>[F:1][c:2]1[c:3]([CH2:4][O:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:31][CH2:38][c:39]4[cH:40][cH:41][c:42]5[c:43]([cH:54]4)[N:44]([CH2:49][CH2:50][CH2:51][O:52][CH3:53])[C:45](=[O:48])[CH2:46][O:47]5)[CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][c:25]4[cH:26][cH:27][cH:28][cH:29][cH:30]4)[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:32][c:33]([F:36])[cH:34][cH:35]1

Participants

3

Reactant 2

HCID 468352236-(chloromethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-oneHCID 68497866HCID 68497866, compound

Product 1

HCID 68501162Benzyl 4-{4-[2-(2,5-difluorobenzyloxy)ethoxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3adefdcaf343499cb28e94579f89ab2c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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