1-(2,5-Xylyl)piperazine → (RS)-3-(2,4-Difluoro-phenyl)-4-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-(propane-2-sulfonyl)-imidazolidin-2-one

HRID 1563267Notes

Reaction equation

HRID 1563267 reaction equation
[CH3:24][c:25]1[c:26]([N:32]2[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]2)[cH:27][c:28]([CH3:31])[cH:29][cH:30]1.[F:1][c:2]1[c:3]([N:9]2[C:10](=[O:23])[N:11]([S:17](=[O:18])(=[O:19])[CH:20]([CH3:21])[CH3:22])[CH2:12][CH:13]2[C:14](=[O:15])[OH:16])[cH:4][cH:5][c:6]([F:8])[cH:7]1>>[F:1][c:2]1[c:3]([N:9]2[C:10](=[O:23])[N:11]([S:17](=[O:18])(=[O:19])[CH:20]([CH3:21])[CH3:22])[CH2:12][CH:13]2[C:14](=[O:16])[N:35]2[CH2:34][CH2:33][N:32]([c:26]3[c:25]([CH3:24])[cH:30][cH:29][c:28]([CH3:31])[cH:27]3)[CH2:37][CH2:36]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

3

Reactant 2

HCID 705421-(2,5-Xylyl)piperazineHCID 67141181(RS)-3-(2,4-difluoro-phenyl)-2-oxo-1-(propane-2-sulfonyl)-imidazolidine-4-carboxylic acid

Product 1

HCID 25027496(RS)-3-(2,4-Difluoro-phenyl)-4-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-1-(propane-2-sulfonyl)-imidazolidin-2-one

Sources & evidence

ORD record
ord-990b1cf06d1b4f43b476caba931332c8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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