Dichloromethane → 1,1-Dimethylethyl 4-(4-bromophenyl)-4-fluoro-1-piperidinecarboxylate

HRID 1564200Notes

Reaction equation

HRID 1564200 reaction equation
[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19](=[O:20])[N:21]1[CH2:22][CH2:23][C:24]([OH:27])([c:28]2[cH:29][cH:30][c:31]([Br:34])[cH:32][cH:33]2)[CH2:25][CH2:26]1.[CH3:1][O:2][CH2:3][CH2:4][N:5]([S:6]([F:7])([F:8])[F:11])[CH2:9][CH2:10][O:12][CH3:13].[Cl:35][CH2:36][Cl:37]>>[F:11][C:24]1([c:28]2[cH:29][cH:30][c:31]([Br:34])[cH:32][cH:33]2)[CH2:23][CH2:22][N:21]([C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:20])[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 2734690(Bis(2-methoxyethyl)amino)sulfur trifluorideHCID 183795571-Boc-4-(4-bromo-phenyl)-piperidin-4-ol

Product 1

HCID 669399181,1-Dimethylethyl 4-(4-bromophenyl)-4-fluoro-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-a59c9a6e40ec490d87934f4eb224b4b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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