Methanol → 2-(4-Fluorobenzyl)-10-hydroxy-4-(hydroxymethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

HRID 1564322Notes

Reaction equation

HRID 1564322 reaction equation
[B:29]([Br:30])([Br:31])[Br:32].[CH3:33][OH:34].[Cl:35][CH2:36][Cl:37].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH2:25][OH:26])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([O:23][CH3:24])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:27][cH:28]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH2:25][OH:26])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([OH:23])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:27][cH:28]1

Participants

5

Reactant 4

HCID 887MethanolHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 688646802-(4-fluorobenzyl)-4-(hydroxymethyl)-10-methoxy-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Product 1

HCID 547043072-(4-Fluorobenzyl)-10-hydroxy-4-(hydroxymethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Sources & evidence

ORD record
ord-aa69a1f82ee243939ba4ccf93f9cf5f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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