Acetate → N-cyclopentyl-2-(4-fluorophenyl)-3-[2-(1-pyrrolid inyl)-4-pyrimidinyl]-6-(trifluoromethyl)pyrazolo[1,5-alpha]pyridin-7-amine

HRID 1564580Notes

Reaction equation

HRID 1564580 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[CH3:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[CH:39]1([NH2:44])[CH2:40][CH2:41][CH2:42][CH2:43]1.[Cl:1][c:2]1[c:3]([C:29]([F:30])([F:31])[F:32])[cH:4][cH:5][c:6]2[n:7]1[n:8][c:9](-[c:22]1[cH:23][cH:24][c:25]([F:28])[cH:26][cH:27]1)[c:10]2-[c:11]1[n:12][c:13]([N:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[n:14][cH:15][cH:16]1.[Cs+:37].[Cs+:38].[O-:53][C:54]([CH3:55])=[O:56].[O-:57][C:58]([CH3:59])=[O:60].[Pd+2:52]>>[c:2]1([NH:44][CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43]2)[c:3]([C:29]([F:30])([F:31])[F:32])[cH:4][cH:5][c:6]2[n:7]1[n:8][c:9](-[c:22]1[cH:23][cH:24][c:25]([F:28])[cH:26][cH:27]1)[c:10]2-[c:11]1[n:12][c:13]([N:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[n:14][cH:15][cH:16]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 2906CyclopentylamineHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 221809127-Chloro-2-(4-fluorophenyl)-3-[2-(1-pyrrolidinyl)-4-pyrimidinyl]-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

Product 1

HCID 10142258N-cyclopentyl-2-(4-fluorophenyl)-3-[2-(1-pyrrolid inyl)-4-pyrimidinyl]-6-(trifluoromethyl)pyrazolo[1,5-alpha]pyridin-7-amine

Sources & evidence

ORD record
ord-88b4cac91404495db61cc1acb267498c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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