[5-(4-Fluoro-phenyl)-2-(3-methoxy-2-triisopropylsilanyloxy-phenyl)-[1,3,4]thiadiazol-3-yl]-(2,4,6-trifluoro-phenyl)-methanone → 6-{2-Cyanomethoxy-3-[5-(4-fluoro-phenyl)-3-(2,4,6-trifluoro-benzoyl)-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-phenoxymethyl}-pyridine-2-carboxylic acid ethyl ester

HRID 1564684Notes

Reaction equation

HRID 1564684 reaction equation
[CH2:43]([CH3:44])[O:45][C:46](=[O:47])[c:48]1[n:49][c:50]([CH2:54][O:55][c:56]2[c:57]([O:64][CH2:65][C:66]#[N:67])[c:58]([CH:62]=[O:63])[cH:59][cH:60][cH:61]2)[cH:51][cH:52][cH:53]1.[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:9][N:10]([C:32](=[O:33])[c:34]3[c:35]([F:42])[cH:36][c:37]([F:41])[cH:38][c:39]3[F:40])[CH:11]([c:13]3[cH:14][cH:15][cH:16][c:17]([O:18][CH3:19])[c:20]3[O:21][Si:22]([CH:23]([CH3:24])[CH3:25])([CH:26]([CH3:27])[CH3:28])[CH:29]([CH3:30])[CH3:31])[S:12]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2=[N:9][N:10]([C:32](=[O:33])[c:34]3[c:35]([F:42])[cH:36][c:37]([F:41])[cH:38][c:39]3[F:40])[CH:62]([c:58]3[c:57]([O:64][CH2:65][C:66]#[N:67])[c:56]([O:55][CH2:54][c:50]4[n:49][c:48]([C:46]([O:45][CH2:43][CH3:44])=[O:47])[cH:53][cH:52][cH:51]4)[cH:61][cH:60][cH:59]3)[S:12]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 67279689[5-(4-Fluoro-phenyl)-2-(3-methoxy-2-triisopropylsilanyloxy-phenyl)-[1,3,4]thiadiazol-3-yl]-(2,4,6-trifluoro-phenyl)-methanoneHCID 86637602HCID 86637602, compound

Product 1

HCID 580257896-{2-Cyanomethoxy-3-[5-(4-fluoro-phenyl)-3-(2,4,6-trifluoro-benzoyl)-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-phenoxymethyl}-pyridine-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-eb69687da0e84fdd9cd90f74a702cacc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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