4-(2-carboxyethyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one → 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-hydroxypropyl)-2H-pyridazin-3-one

HRID 1565227Notes

Reaction equation

HRID 1565227 reaction equation
[C:32](=[O:33])([OH:34])[CH2:35][CH2:36][c:37]1[c:38](=[O:56])[n:39]([CH2:52][CH:53]2[CH2:54][CH2:55]2)[n:40][c:41](-[c:43]2[cH:44][c:45]([F:51])[c:46]([O:49][CH3:50])[cH:47][cH:48]2)[cH:42]1.[F:1][c:2]1[cH:3][c:4]([F:5])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([CH2:12][N:13]2[C:14](=[O:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[C:22]2=[O:23])[c:24](=[O:25])[n:26]([CH2:27][CH:28]([CH3:29])[CH3:30])[n:31]1>>[CH2:32]([OH:33])[CH2:35][CH2:36][c:37]1[c:38](=[O:56])[n:39]([CH2:52][CH:53]2[CH2:54][CH2:55]2)[n:40][c:41](-[c:43]2[cH:44][c:45]([F:51])[c:46]([O:49][CH3:50])[cH:47][cH:48]2)[cH:42]1

Participants

3

Reactant 2

HCID 219914104-(2-carboxyethyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneHCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one

Product 1

HCID 219914722-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-hydroxypropyl)-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-7a2eb95f77dd44f0b851fb187df87195
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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