Methanol → [(1-{2-[3-Fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-azetidinyl)methyl]amine

HRID 1565659Notes

Reaction equation

HRID 1565659 reaction equation
[CH3:32][OH:33].[OH-:34].[OH-:35].[Pd+2:36].[c:1]1([CH2:2][N:8]([C:3](=[O:4])[O-:5])[CH2:12][CH:13]2[CH2:14][N:15]([CH2:17][CH2:18][c:19]3[c:20]([F:31])[cH:21][n:22][c:23]4[cH:24][cH:25][c:26]([O:29][CH3:30])[n:27][c:28]34)[CH2:16]2)[cH:6][cH:7][cH:9][cH:10][cH:11]1>>[NH2:8][CH2:12][CH:13]1[CH2:14][N:15]([CH2:17][CH2:18][c:19]2[c:20]([F:31])[cH:21][n:22][c:23]3[cH:24][cH:25][c:26]([O:29][CH3:30])[n:27][c:28]23)[CH2:16]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 178487916HCID 178487916, compound

Product 1

HCID 58989533[(1-{2-[3-Fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-azetidinyl)methyl]amine

Sources & evidence

ORD record
ord-53e89dfdfc3e4489be41aa316c9137b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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