5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → 5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-(2-hydroxy-1,1-dimethyl-ethylsulfamoyl)-4-methyl-thiazol-2-yl]-amide

HRID 1566005Notes

Reaction equation

HRID 1566005 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:20](=[O:21])[OH:22])[cH:6][cH:7]1.[OH:23][CH2:24][C:25]([CH3:26])([CH3:27])[NH:28][S:29](=[O:30])(=[O:31])[c:32]1[c:33]([CH3:38])[n:34][c:35]([NH2:37])[s:36]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:20](=[O:22])[NH:37][c:35]2[n:34][c:33]([CH3:38])[c:32]([S:29]([NH:28][C:25]([CH2:24][OH:23])([CH3:26])[CH3:27])(=[O:30])=[O:31])[s:36]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 666504695-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 866070982-Amino-4-methyl-thiazole-5-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide

Product 1

HCID 119965565-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-(2-hydroxy-1,1-dimethyl-ethylsulfamoyl)-4-methyl-thiazol-2-yl]-amide

Sources & evidence

ORD record
ord-4834f490dc1a43419179dd8a18212050
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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