Tert-butyl 7-amino-4,5-dihydro-1H-benzo[D]azepine-3(2H)-carboxylate → 7-[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

HRID 1566355Notes

Reaction equation

HRID 1566355 reaction equation
[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[N:30]1[CH2:31][CH2:32][c:33]2[c:34]([cH:37][cH:38][c:39]([NH2:41])[cH:40]2)[CH2:35][CH2:36]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([O:20][CH3:21])[cH:12][cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]3)[cH:7][cH:8][cH:9]2)[n:22]1>>[c:2]1([NH:41][c:39]2[cH:38][cH:37][c:34]3[c:33]([cH:40]2)[CH2:32][CH2:31][N:30]([C:28]([O:27][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:29])[CH2:36][CH2:35]3)[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([O:20][CH3:21])[cH:12][cH:13][c:14]([C:16]([F:17])([F:18])[F:19])[cH:15]3)[cH:7][cH:8][cH:9]2)[n:22]1

Participants

3

Reactant 2

HCID 11402789Tert-butyl 7-amino-4,5-dihydro-1H-benzo[D]azepine-3(2H)-carboxylateHCID 674789492-Chloro-8-(2-methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 596124977-[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-5d58eeae30a745ddb3fb6c957aed98bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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