1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine → 1-(2,5-Dichlorobenzyl)-4-methyl-7-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

HRID 1566447Notes

Reaction equation

HRID 1566447 reaction equation
[CH3:22][N:23]1[CH2:24][CH2:25][N:26]([c:29]2[n:30][cH:31][c:32]([B:35]3[O:36][C:37]([CH3:38])([CH3:39])[C:40]([CH3:41])([CH3:42])[O:43]3)[cH:33][cH:34]2)[CH2:27][CH2:28]1.[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14]([I:16])[cH:15]3)[N:8]([CH3:11])[CH2:9][CH2:10]2)[cH:17][c:18]([Cl:21])[cH:19][cH:20]1>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14](-[c:32]4[cH:31][n:30][c:29]([N:26]5[CH2:25][CH2:24][N:23]([CH3:22])[CH2:28][CH2:27]5)[cH:34][cH:33]4)[cH:15]3)[N:8]([CH3:11])[CH2:9][CH2:10]2)[cH:17][c:18]([Cl:21])[cH:19][cH:20]1

Participants

3

Reactant 2

HCID 27696181-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazineHCID 578859471-(2,5-Dichlorobenzyl)-7-iodo-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 469067161-(2,5-Dichlorobenzyl)-4-methyl-7-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Sources & evidence

ORD record
ord-3bdc8196a8cb49cca23e874405f7c7cd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…