6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → 6-(cyclopropylmethoxy)-N-[1-cyclopropyl-3-(2-methoxyethoxy)propan-2-yl]-5-(3,3-difluoroazetidin-1-yl)pyridine-2-carboxamide
Reaction equation
[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:13])[OH:14])[n:11]2)[CH2:2][CH2:3]1.[CH:21]1([CH2:24][CH:25]([CH2:26][O:27][CH2:28][CH2:29][O:30][CH3:31])[NH2:32])[CH2:22][CH2:23]1>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:14])[NH:32][CH:25]([CH2:24][CH:21]3[CH2:22][CH2:23]3)[CH2:26][O:27][CH2:28][CH2:29][O:30][CH3:31])[n:11]2)[CH2:2][CH2:3]1Participants
3
Sources & evidence
- ORD record
- ord-d4bcd423f8f14cbda69c68f686247ab8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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