Methanol → 3-(2-chlorophenyl)-7-(1-ethoxycarbonylpiperidin-4-ylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

HRID 1568414Notes

Reaction equation

HRID 1568414 reaction equation
[CH3:41][OH:42].[Cl:1][c:2]1[c:3]([N:8]2[C:9](=[O:28])[NH:10][c:11]3[n:12][c:13]([S:18]([CH2:19][c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)(=[O:26])=[O:27])[n:14][cH:15][c:16]3[CH2:17]2)[cH:4][cH:5][cH:6][cH:7]1.[NH2:29][CH:30]1[CH2:31][CH2:32][N:33]([C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:34][CH2:35]1>>[Cl:1][c:2]1[c:3]([N:8]2[C:9](=[O:28])[NH:10][c:11]3[n:12][c:13]([NH:29][CH:30]4[CH2:31][CH2:32][N:33]([C:36](=[O:37])[O:38][CH2:39][CH3:40])[CH2:34][CH2:35]4)[n:14][cH:15][c:16]3[CH2:17]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 100867Ethyl 4-amino-1-piperidinecarboxylateHCID 180024743-(2-chlorophenyl)-7-benzylsulfonyl-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one

Product 1

HCID 184254663-(2-chlorophenyl)-7-(1-ethoxycarbonylpiperidin-4-ylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Sources & evidence

ORD record
ord-7a348bab01004bf4b852e7a82215bd75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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