Pyridine → isopropyl 2-chloro-4-fluoro-5-[6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate

HRID 1568949Notes

Reaction equation

HRID 1568949 reaction equation
[CH2:27]([C:28]#[CH:29])[OH:30].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH:7]([CH3:8])[CH3:9])[cH:10][c:11](-[n:15]2[c:16]([Cl:26])[n:17][c:18]([C:22]([F:23])([F:24])[F:25])[cH:19][c:20]2=[O:21])[c:12]([F:14])[cH:13]1.[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH:7]([CH3:8])[CH3:9])[cH:10][c:11](-[n:15]2[c:16]([O:30][CH2:27][C:28]#[CH:29])[n:17][c:18]([C:22]([F:23])([F:24])[F:25])[cH:19][c:20]2=[O:21])[c:12]([F:14])[cH:13]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7859Propargyl alcoholHCID 19994245isopropyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate

Product 1

HCID 21270783isopropyl 2-chloro-4-fluoro-5-[6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate

Sources & evidence

ORD record
ord-de11ee2d54f64a3990b2d11f5a6810f5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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