2-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamide → methyl (5-(3-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-3-oxopropyl)pyridin-2-yl)carbamate

HRID 1569996Notes

Reaction equation

HRID 1569996 reaction equation
[CH3:35][O:36][C:37](=[O:38])[NH:39][c:40]1[cH:41][cH:42][c:43]([CH2:46][CH2:47][C:48](=[O:49])[OH:50])[cH:44][n:45]1.[Cl:51][c:52]1[c:53]([CH2:54][O:55][c:56]2[c:57]3[n:58][c:59]([O:60][CH3:61])[n:62]([CH2:63][c:64]4[cH:65][cH:66][cH:67][cH:68][n:69]4)[c:70]3[cH:71][cH:72][cH:73]2)[c:74]([Cl:75])[cH:76][cH:77][c:78]1[N:79]([CH3:80])[C:81](=[O:82])[CH2:83][NH:84][C:85](=[O:86])[CH2:87][CH2:88][c:89]1[cH:90][cH:91][c:92]([C:93]([NH:94][CH2:95][CH2:96][O:97][CH3:98])=[O:99])[cH:100][cH:101]1.[NH2:1][CH2:2][C:3](=[O:4])[N:5]([CH3:6])[c:7]1[c:8]([Cl:34])[c:9]([CH2:14][O:15][c:16]2[cH:17][cH:18][cH:19][c:20]3[n:21]([CH2:27][c:28]4[n:29][cH:30][cH:31][cH:32][cH:33]4)[c:22]([O:25][CH3:26])[n:23][c:24]23)[c:10]([Cl:13])[cH:11][cH:12]1>>[NH:1]([CH2:2][C:3](=[O:4])[N:5]([CH3:6])[c:7]1[c:8]([Cl:34])[c:9]([CH2:14][O:15][c:16]2[cH:17][cH:18][cH:19][c:20]3[n:21]([CH2:27][c:28]4[n:29][cH:30][cH:31][cH:32][cH:33]4)[c:22]([O:25][CH3:26])[n:23][c:24]23)[c:10]([Cl:13])[cH:11][cH:12]1)[C:48]([CH2:47][CH2:46][c:43]1[cH:42][cH:41][c:40]([NH:39][C:37]([O:36][CH3:35])=[O:38])[n:45][cH:44]1)=[O:49]

Participants

4

Reactant 3

HCID 667603852-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamideHCID 667607703-(6-((Methoxycarbonyl)amino)pyridin-3-yl)propanoic acidHCID 667609784-(3-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-3-oxopropyl)-N-(2-methoxyethyl)benzamide

Product 1

HCID 68026500methyl (5-(3-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-3-oxopropyl)pyridin-2-yl)carbamate

Sources & evidence

ORD record
ord-10fb9f8424b44848ab08fb836dee5672
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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