Methanol → 4-(Aminomethyl)-1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-ol

HRID 1570016Notes

Reaction equation

HRID 1570016 reaction equation
[CH3:34][OH:35].[OH-:36].[OH-:37].[Pd+2:38].[c:1]1([CH2:2][N:8]([C:3](=[O:4])[O-:5])[CH2:12][CH:13]2[CH2:14][N:15]([CH2:19][CH2:20][c:21]3[c:22]([F:33])[cH:23][n:24][c:25]4[cH:26][cH:27][c:28]([O:31][CH3:32])[n:29][c:30]34)[CH2:16][CH:17]2[OH:18])[cH:6][cH:7][cH:9][cH:10][cH:11]1>>[NH2:8][CH2:12][CH:13]1[CH2:14][N:15]([CH2:19][CH2:20][c:21]2[c:22]([F:33])[cH:23][n:24][c:25]3[cH:26][cH:27][c:28]([O:31][CH3:32])[n:29][c:30]23)[CH2:16][CH:17]1[OH:18]

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 178487921HCID 178487921, compound

Product 1

HCID 685769574-(Aminomethyl)-1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-ol

Sources & evidence

ORD record
ord-f75d860a517241fa977b35571049b639
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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