6-chloro-1H-indole-3-carboxylic acid → 5-Bromo-1'-[(6-chloro-1H-indol-3-yl)carbonyl]spiro[indole-3,4'-piperidin]-2(1H)-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][C:6](=[O:11])[C:5]21[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1.[Cl:17][c:18]1[cH:19][cH:20][c:21]2[c:22]([C:27](=[O:28])[OH:29])[cH:23][nH:24][c:25]2[cH:26]1>>[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][C:6](=[O:11])[C:5]21[CH2:12][CH2:13][N:14]([C:27]([c:22]2[c:21]3[cH:20][cH:19][c:18]([Cl:17])[cH:26][c:25]3[nH:24][cH:23]2)=[O:28])[CH2:15][CH2:16]1Participants
3
Sources & evidence
- ORD record
- ord-b5d457542ba443a8bbf686ed2e322ce2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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