Diethyl Ether → Ethyl 2,6-difluoro-4-[(3-hydroxy-4-chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

HRID 1570553Notes

Reaction equation

HRID 1570553 reaction equation
[CH2:37]([O:38][CH2:39][CH3:40])[CH3:41].[Cl:42][CH2:43][Cl:44].[F:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH2:7][CH3:8])[c:9]([F:31])[cH:10][c:11]([NH:13][C:14](=[O:15])[c:16]2[cH:17][c:18]3[c:23]([cH:24][c:25]2[OH:26])[C:22]([CH3:27])([CH3:28])[CH2:21][CH2:20][C:19]3([CH3:29])[CH3:30])[cH:12]1.[S:32]([Cl:33])(=[O:34])([Cl:35])=[O:36]>>[F:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH2:7][CH3:8])[c:9]([F:31])[cH:10][c:11]([NH:13][C:14](=[O:15])[c:16]2[cH:17][c:18]3[c:23]([c:24]([Cl:35])[c:25]2[OH:26])[C:22]([CH3:27])([CH3:28])[CH2:21][CH2:20][C:19]3([CH3:29])[CH3:30])[cH:12]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 24648Sulfuryl chlorideHCID 22465056Ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Product 1

HCID 10298591Ethyl 2,6-difluoro-4-[(3-hydroxy-4-chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Sources & evidence

ORD record
ord-4d97e7a52af44ea38fc4e7defeb9cb07
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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