Methanol → 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}amide

HRID 1570573Notes

Reaction equation

HRID 1570573 reaction equation
[CH3:17][O:18][c:19]1[cH:20][c:21]([NH2:35])[cH:22][cH:23][c:24]1[O:25][CH2:26][CH2:27][N:28]1[CH2:29][CH2:30][CH:31]([CH3:34])[CH2:32][CH2:33]1.[CH3:36][OH:37].[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:15])[OH:16])[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[Cl:38][CH2:39][Cl:40]>>[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:16])[NH:35][c:21]2[cH:20][c:19]([O:18][CH3:17])[c:24]([O:25][CH2:26][CH2:27][N:28]3[CH2:29][CH2:30][CH:31]([CH3:34])[CH2:32][CH2:33]3)[cH:23][cH:22]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

5

Reactant 4

HCID 887MethanolHCID 6344DichloromethaneHCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acidHCID 688191123-Methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylamine

Product 1

HCID 578456833-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-{3-methoxy-4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}amide

Sources & evidence

ORD record
ord-e4223ce1d65e491bbe60db52f65793ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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