Dichloromethane → 1'-(4-Chlorophenyl)-5',7',8'-trimethyl-1',4'-dihydro-2'H-spiro[cyclobutane-1,3'-quinolin]-6'-ol

HRID 1570625Notes

Reaction equation

HRID 1570625 reaction equation
[B:26]([Br:27])([Br:28])[Br:29].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][C:10]3([CH2:11][CH2:12][CH2:13]3)[CH2:14][c:15]3[c:16]([CH3:25])[c:17]([O:23][CH3:24])[c:18]([CH3:22])[c:19]([CH3:21])[c:20]32)[cH:6][cH:7]1.[Cl:30][CH2:31][Cl:32]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][C:10]3([CH2:11][CH2:12][CH2:13]3)[CH2:14][c:15]3[c:16]([CH3:25])[c:17]([OH:23])[c:18]([CH3:22])[c:19]([CH3:21])[c:20]32)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25134Boron tribromideHCID 690532931'-(4-chlorophenyl)-6'-methoxy-5',7',8'-trimethyl-2',4'-dihydro-1'H-spiro[cyclobutane-1,3'-quinoline]

Product 1

HCID 116242921'-(4-Chlorophenyl)-5',7',8'-trimethyl-1',4'-dihydro-2'H-spiro[cyclobutane-1,3'-quinolin]-6'-ol

Sources & evidence

ORD record
ord-e9bc3209611a4fd696faf18d44d28cd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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