2,4-Dichloro-5-fluoropyrimidine → 2-chloro-N4-[3-[[4-(ethoxycarbonyl)piperidino]carbonyl]phenyl]-5-fluoro-4-pyrimidineamine
Reaction equation
[CH2:10]([CH3:11])[O:12][C:13](=[O:14])[CH:15]1[CH2:16][CH2:17][N:18]([C:21](=[O:22])[c:23]2[cH:24][c:25]([NH2:26])[cH:27][cH:28][cH:29]2)[CH2:19][CH2:20]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:26][c:25]2[cH:24][c:23]([C:21]([N:18]3[CH2:17][CH2:16][CH:15]([C:13]([O:12][CH2:10][CH3:11])=[O:14])[CH2:20][CH2:19]3)=[O:22])[cH:29][cH:28][cH:27]2)[n:7]1Participants
3
Sources & evidence
- ORD record
- ord-adc7062b65af4bd89a0e8130d39f5782
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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