Dichloromethane → rac-(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carboxylic acid pyridin-4-ylamide

HRID 1571045Notes

Reaction equation

HRID 1571045 reaction equation
[Cl:1][c:2]1[c:3]([F:28])[c:4]([CH:8]2[NH:9][CH2:10][CH:11]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[C:12]2([C:13]#[N:14])[c:15]2[c:16]([F:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:5][cH:6][cH:7]1.[Cl:38][CH2:39][Cl:40].[N:29](=[C:30]=[O:31])[c:32]1[cH:33][cH:34][n:35][cH:36][cH:37]1>>[Cl:1][c:2]1[c:3]([F:28])[c:4]([CH:8]2[N:9]([C:30]([NH:29][c:32]3[cH:33][cH:34][n:35][cH:36][cH:37]3)=[O:31])[CH2:10][CH:11]([CH2:23][C:24]([CH3:25])([CH3:26])[CH3:27])[C:12]2([C:13]#[N:14])[c:15]2[c:16]([F:22])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 116367964-IsocyanatopyridineHCID 67095372rac-(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-4-(2,2-dimethyl-propyl)-pyrrolidine-3-carbonitrile

Product 1

HCID 67095544rac-(2S,3S,4S)-2-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-4-(2,2-dimethyl-propyl)-pyrrolidine-1-carboxylic acid pyridin-4-ylamide

Sources & evidence

ORD record
ord-8c76531d113c4588894a9f65d985b239
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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