Methanol → tert-Butyl 3-((6-chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)benzoate

HRID 1571106Notes

Reaction equation

HRID 1571106 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][c:9]2[cH:10][c:11]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[cH:19][cH:20][cH:21]2)[cH:22][cH:23]1.[CH3:49][OH:50].[Cl:24][c:25]1[cH:26][c:27]([N:36]([CH:37]2[CH2:38][CH2:39]2)[CH2:40][c:41]2[cH:42][cH:43][c:44]([O:45][CH3:46])[cH:47][cH:48]2)[c:28]2[n:29]([n:30]1)[c:31]([C:34]#[N:35])[cH:32][n:33]2>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]([c:9]2[cH:10][c:11]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[cH:19][cH:20][cH:21]2)[c:27]2[cH:26][c:25]([Cl:24])[n:30][n:29]3[c:28]2[n:33][cH:32][c:31]3[C:34]#[N:35])[cH:22][cH:23]1

Participants

4

Reactant 3

HCID 887MethanolHCID 59313743tert-Butyl 3-(4-methoxybenzylamino)benzoateHCID 593137576-Chloro-8-(cyclopropyl(4-methoxybenzyl)amino)imidazo[1,2-b]pyridazine-3-carbonitrile

Product 1

HCID 59314053tert-Butyl 3-((6-chloro-3-cyanoimidazo[1,2-b]pyridazin-8-yl)(4-methoxybenzyl)amino)benzoate

Sources & evidence

ORD record
ord-df798abe974b480a9ed067a7b330aa6f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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