Methanol → 4-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol

HRID 1571444Notes

Reaction equation

HRID 1571444 reaction equation
[B:51]([Br:52])([Br:53])[Br:54].[CH3:28][O:29][c:30]1[cH:31][c:32]([C:47]([F:48])([F:49])[F:50])[c:33]([NH:36][c:37]2[s:38][c:39](-[c:42]3[cH:43][s:44][cH:45][cH:46]3)[cH:40][n:41]2)[cH:34][cH:35]1.[CH3:58][OH:59].[Cl:55][CH2:56][Cl:57].[N:1]1([CH2:2][CH2:3][O:4][c:5]2[cH:6][cH:7][c:8]([NH:9][c:10]3[s:11][c:12](-[c:13]4[cH:14][cH:15][c:16]([OH:17])[cH:18][cH:19]4)[cH:20][n:21]3)[cH:22][cH:23]2)[CH2:24][CH2:25][CH2:26][CH2:27]1>>[OH:29][c:30]1[cH:31][c:32]([C:47]([F:48])([F:49])[F:50])[c:33]([NH:36][c:37]2[s:38][c:39](-[c:42]3[cH:43][s:44][cH:45][cH:46]3)[cH:40][n:41]2)[cH:34][cH:35]1

Participants

6

Reactant 5

HCID 887MethanolHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 111882064-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenolHCID 58923518(4-Methoxy-2-trifluoromethyl-phenyl)-(5-thiophen-3-yl-thiazol-2-yl)-amine

Product 1

HCID 589235234-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol

Sources & evidence

ORD record
ord-99529c3e22394e16a1fecf5f0ebddfe3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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