Ammonium → Tert-butyl 2-(4-amino-3-fluorophenyl)morpholine-4-carboxylate

HRID 157172Notes

Reaction equation

HRID 157172 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([c:14]2[cH:15][c:16]([F:34])[c:17]([N:20]=[C:21]([c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)[cH:18][cH:19]2)[O:11][CH2:12][CH2:13]1.[CH3:39][OH:40].[CH:35]([O-:36])=[O:37].[NH4+:38]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([c:14]2[cH:15][c:16]([F:34])[c:17]([NH2:20])[cH:18][cH:19]2)[O:11][CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 223AmmoniumHCID 283FormateHCID 887MethanolHCID 86671396(RS)-2-[4-(benzhydrylidene-amino)-3-fluoro-phenyl]-morpholine-4-carboxylic acid tert-butyl ester

Product 1

HCID 68325450Tert-butyl 2-(4-amino-3-fluorophenyl)morpholine-4-carboxylate

Sources & evidence

ORD record
ord-805ffea5f46c403e97c07b039033c1a7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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