2-(4-Fluorophenyl)acetyl isocyanate → tert-butyl N-[1-[3-[4-[2-fluoro-4-[[2-(4-fluorophenyl)acetyl]carbamoylamino]phenoxy]-3-pyridinyl]prop-2-enoyl]piperidin-4-yl]carbamate
Reaction equation
[F:34][c:35]1[cH:36][cH:37][c:38]([CH2:41][C:42](=[O:43])[N:44]=[C:45]=[O:46])[cH:39][cH:40]1.[NH2:1][c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[c:8]([CH:13]=[CH:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][CH:20]([NH:23][C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:21][CH2:22]3)[cH:9][n:10][cH:11][cH:12]2)[cH:31][cH:32]1>>[NH:1]([c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[c:8]([CH:13]=[CH:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][CH:20]([NH:23][C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:21][CH2:22]3)[cH:9][n:10][cH:11][cH:12]2)[cH:31][cH:32]1)[C:45]([NH:44][C:42]([CH2:41][c:38]1[cH:37][cH:36][c:35]([F:34])[cH:40][cH:39]1)=[O:43])=[O:46]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-55433ae658254d6a8bcda2d21844d4ab
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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