Toluene → 3-(2,3-Dihydro-7-methoxy-2,2-dimethyl-5-benzofuranyl)-3-hydroxy-2,2-dimethylpropionic acid ethyl ester

HRID 1572144Notes

Reaction equation

HRID 1572144 reaction equation
[CH2:16]([CH3:17])[O:18][C:19]([C:20]([CH3:21])([CH3:22])[Br:23])=[O:24].[CH3:1][O:2][c:3]1[cH:4][c:5]([CH:14]=[O:15])[cH:6][c:7]2[c:11]1[O:10][C:9]([CH3:12])([CH3:13])[CH2:8]2.[CH3:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[Zn:32]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH:14]([OH:15])[C:20]([C:19]([O:18][CH2:16][CH3:17])=[O:24])([CH3:21])[CH3:22])[cH:6][c:7]2[c:11]1[O:10][C:9]([CH3:12])([CH3:13])[CH2:8]2

Participants

5

Reactant 4

HCID 1140TolueneHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 23994ZincHCID 223437212,3-Dihydro-7-methoxy-2,2-dimethyl-5-benzofurancarboxaldehyde

Product 1

HCID 695644183-(2,3-Dihydro-7-methoxy-2,2-dimethyl-5-benzofuranyl)-3-hydroxy-2,2-dimethylpropionic acid ethyl ester

Sources & evidence

ORD record
ord-973ab73fddcb422088d47de7292c0eb3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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