Potassium Cation → Fruquintinib

HRID 1572149Notes

Reaction equation

HRID 1572149 reaction equation
[CH3:37][C:38]#[N:39].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12.[K+:31].[K+:32].[O-:33][C:34]([O-:35])=[O:36].[OH:16][c:17]1[cH:18][c:19]2[c:20]([c:21]([C:25](=[O:26])[NH:27][CH3:28])[c:22]([CH3:24])[o:23]2)[cH:29][cH:30]1>>[c:2]1([O:16][c:17]2[cH:18][c:19]3[c:20]([c:21]([C:25](=[O:26])[NH:27][CH3:28])[c:22]([CH3:24])[o:23]3)[cH:29][cH:30]2)[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 167551736-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide

Product 1

HCID 44480399Fruquintinib

Sources & evidence

ORD record
ord-432e1e76fddf48b19b36b2da9b23f50f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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