2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-thiazol-4-yl}-pyrimidin-2-ylamine

HRID 1572486Notes

Reaction equation

HRID 1572486 reaction equation
[Br:1][c:2]1[n:3][c:4](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[cH:12]2)[s:5][cH:6]1.[NH2:24][c:25]1[n:26][cH:27][c:28]([B:31]2[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]2)[cH:29][n:30]1>>[c:2]1(-[c:28]2[cH:27][n:26][c:25]([NH2:24])[n:30][cH:29]2)[n:3][c:4](-[c:7]2[n:8][c:9]([CH3:23])[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[cH:12]2)[s:5][cH:6]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 574687942-(4-Bromo-thiazol-2-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 247604325-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-thiazol-4-yl}-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-367efe63417341d68c3424c4a6f4bf04
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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