8-Methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamine → 5-Chloro-N(2)-[8-methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-N(4)-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine

HRID 1573758Notes

Reaction equation

HRID 1573758 reaction equation
[CH3:24][O:25][c:26]1[c:27]([NH2:45])[cH:28][c:29]2[c:30]([cH:44]1)[CH2:31][CH2:32][N:33]([CH2:36][CH2:37][N:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1)[CH2:34][CH2:35]2.[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([O:21][CH3:22])[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:45][c:27]2[c:26]([O:25][CH3:24])[cH:44][c:30]3[c:29]([cH:28]2)[CH2:35][CH2:34][N:33]([CH2:36][CH2:37][N:38]2[CH2:39][CH2:40][O:41][CH2:42][CH2:43]2)[CH2:32][CH2:31]3)[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([O:21][CH3:22])[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 672641368-Methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ylamineHCID 86633851(2,5-Dichloropyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 672641465-Chloro-N(2)-[8-methoxy-3-(2-morpholin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-N(4)-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-1a15bc5cd035430a952a1ee49e32db78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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