trans-N-Benzyl-2,6-dimethylpiperidin-4-one → HCID 68499919, compound

HRID 15738Notes

Reaction equation

HRID 15738 reaction equation
C([N:8]1[C@@H:13]([CH3:14])[CH2:12][C:11](=[O:15])[CH2:10][C@@H:9]1[CH3:16])C1C=CC=CC=1>CCO.[Pd]>[CH3:16][C@H:9]1[CH2:10][C:11](=[O:15])[CH2:12][C@H:13]([CH3:14])[NH:8]1

Participants

4

Reactant 1

HCID 68495982trans-N-Benzyl-2,6-dimethylpiperidin-4-one

Product 1

HCID 68499919HCID 68499919, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

trans-N-Benzyl-2,6-dimethylpiperidin-4-one (91; 7.5 g) was dissolved in EtOH (20 mL) and the catalyst (0.8 g, Pd/C5%) was added. The slurry was vigorously stirred and kept under a hydrogen atmosphere (60 psi) for 90 hr. The catalyst was removed by filtration through Celite and the filtrate was evaporated at 3 mmHg/40° C. The residue (ca. 5.2 g) was used without further purification.

Workup

  1. customfor 90 hr
  2. customThe catalyst was removed by filtration through Celite
  3. customthe filtrate was evaporated at 3 mmHg/40° C
  4. customThe residue (ca. 5.2 g) was used without further purification

Sources & evidence

ORD record
ord-2086be43017d4a98bc69869bb1ccc20d
Source dataset
uspto-grants-2010_06
Patent number
US07732609B2

Reaction notes

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