2-(4-Aminomethyl-phenoxy)-2-methyl-propionic acid ethyl ester → 2-[4-({2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetylamino}-methyl)-phenoxy]-2-methyl-propionic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([CH2:15][NH2:16])[cH:13][cH:14]1)=[O:17].[CH:18]1([c:21]2[n:22][c:23](-[c:31]3[cH:32][cH:33][c:34]([C:37]([F:38])([F:39])[F:40])[cH:35][cH:36]3)[n:24][cH:25][c:26]2[CH2:27][C:28](=[O:29])[OH:30])[CH2:19][CH2:20]1.[Cl:41][CH2:42][c:43]1[c:44]([CH:45]2[CH2:46][CH2:47]2)[n:48][c:49](-[c:50]2[cH:51][cH:52][c:53]([C:54]([F:55])([F:56])[F:57])[cH:58][cH:59]2)[n:60][cH:61]1>>[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([CH2:15][NH:16][C:28]([CH2:27][c:26]2[c:21]([CH:18]3[CH2:19][CH2:20]3)[n:22][c:23](-[c:31]3[cH:32][cH:33][c:34]([C:37]([F:38])([F:39])[F:40])[cH:35][cH:36]3)[n:24][cH:25]2)=[O:29])[cH:13][cH:14]1)=[O:17]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-857f9c510b0f48b89c03f08232e85cbe
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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