2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

HRID 1574350Notes

Reaction equation

HRID 1574350 reaction equation
[Br:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([C:24]([F:25])([F:26])[F:27])[cH:10][c:11](-[c:13]3[cH:14][c:15]([CH3:23])[c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1.[NH2:28][c:29]1[n:30][cH:31][c:32]([B:35]2[O:36][C:37]([CH3:38])([CH3:39])[C:40]([CH3:41])([CH3:42])[O:43]2)[cH:33][n:34]1>>[c:2]1(-[c:32]2[cH:31][n:30][c:29]([NH2:28])[n:34][cH:33]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([C:24]([F:25])([F:26])[F:27])[cH:10][c:11](-[c:13]3[cH:14][c:15]([CH3:23])[c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 574687652-(4-Bromo-imidazol-1-yl)-4-(3-methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 602094025-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-87080280887646ef908aaebb620aa703
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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