2-(5-(2-(Aminomethyl)-4-fluorophenoxy)-1H-indazol-1-yl)ethanol → 1-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)phenyl)methyl)-3-(3-(1-hydroxy-2-methylpropan-2-yl)-1-p-tolyl-1H-pyrazol-5-yl)urea

HRID 1574424Notes

Reaction equation

HRID 1574424 reaction equation
[NH2:27][CH2:28][c:29]1[c:30]([O:31][c:32]2[cH:33][c:34]3[cH:35][n:36][n:37]([CH2:41][CH2:42][OH:43])[c:38]3[cH:39][cH:40]2)[cH:44][cH:45][c:46]([F:48])[cH:47]1.[OH:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[n:7][n:8](-[c:20]2[cH:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]2)[c:9]([NH:11][C:12]([O:13][CH2:14][C:15]([Cl:16])([Cl:17])[Cl:18])=[O:19])[cH:10]1>>[OH:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[n:7][n:8](-[c:20]2[cH:21][cH:22][c:23]([CH3:26])[cH:24][cH:25]2)[c:9]([NH:11][C:12](=[O:19])[NH:27][CH2:28][c:29]2[c:30]([O:31][c:32]3[cH:33][c:34]4[cH:35][n:36][n:37]([CH2:41][CH2:42][OH:43])[c:38]4[cH:39][cH:40]3)[cH:44][cH:45][c:46]([F:48])[cH:47]2)[cH:10]1

Participants

3

Reactant 2

HCID 445421222-(5-(2-(Aminomethyl)-4-fluorophenoxy)-1H-indazol-1-yl)ethanolHCID 445422572,2,2-Trichloroethyl 3-(1-hydroxy-2-methylpropan-2-yl)-1-p-tolyl-1H-pyrazol-5-ylcarbamate

Product 1

HCID 252074011-((5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)phenyl)methyl)-3-(3-(1-hydroxy-2-methylpropan-2-yl)-1-p-tolyl-1H-pyrazol-5-yl)urea

Sources & evidence

ORD record
ord-a6d3585f5eb14383b7a37507e1ab6ed1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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