4-(Bromomethyl)oxane → 5,6-difluoro-1'-(tetrahydro-2H-pyran-4-ylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 1574785Notes

Reaction equation

HRID 1574785 reaction equation
[Br:1][CH2:2][CH:3]1[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1.[Br:9][CH2:10][c:11]1[o:12][c:13]([C:14]([F:15])([F:16])[F:17])[cH:18][cH:19]1.[CH3:40][c:41]1[c:42]2[cH:43][c:44]3[c:57]([cH:58][c:59]2[o:60][n:61]1)[O:56][CH2:55][C:45]31[c:46]2[c:47]([cH:48][cH:49][cH:50][cH:51]2)[NH:52][C:53]1=[O:54].[F:20][c:21]1[c:22]([F:39])[cH:23][c:24]2[c:25]([cH:38]1)[C:26]1([CH2:27][O:28]2)[C:29](=[O:37])[NH:30][c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]21>>[CH2:2]([CH:3]1[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1)[N:30]1[C:29](=[O:37])[C:26]2([c:25]3[c:24]([cH:23][c:22]([F:39])[c:21]([F:20])[cH:38]3)[O:28][CH2:27]2)[c:36]2[c:31]1[cH:32][cH:33][cH:34][cH:35]2

Participants

5

Reactant 4

HCID 27732864-(Bromomethyl)oxaneHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 593524533-methylspiro[furo[3,2-f][1,2]benzisoxazole-5,3'-indol]-2'(1H)-oneHCID 593525695,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Product 1

HCID 593527165,6-difluoro-1'-(tetrahydro-2H-pyran-4-ylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d816c2f67fd04f44be08260d7533d743
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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